Daqing Ma
Imperial College London, Chelsea and Westminster Hospital, UK
Title: The role of necroptosis in the pathogenesis of lung injury following kidney transplant and beyond
Biography
Biography: Daqing Ma
Abstract
Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase-independent. Increasing evidence has implicated necroptosis in the pathogenesis of disease, including ischemic injury, neurodegeneration, viral infection and many others. Key players of the necroptosis signalling pathway are now widely recognized as therapeutic targets. Necrostatins may be developed as potent inhibitors of necroptosis, targeting the activity of RIP1. Necrostatin-1, the first generation of necrostatins, has been shown to confer potent protective effects in different animal models. This lecture covers the role of necroptosis in the pathogenesis of lung injury after kidney transplant and other solid organ injury following ischaemia/reperfusion.
