4^th International Conference and Exhibition on Lung & Respiratory Care August 01-02, 2016 Manchester, UK

Mi-Jin Kang is working as a Faculty member in Department of Radiology in Sanggye Paik Hospital at Inje University College of Medicine, Korea. Research experience includes various programs, contributions and participation in different countries for diverse fields of study. His research interests mainly include Lingular Arteries.

The purpose of this study is to describe n anatomical variations occurring in the lingular artery (LiA) in terms of their origin, and to determine the frequency of each variation. From June 2010 to July 2010, 260 patients underwent contrast enhanced CT scan performed using a 64-channel CT scanner. CT interpretation was performed by two radiologist (M.J.K, K.E.B: 8 and 4 years of experience, respectively) in consensus. And the images were viewed with a mediastina window setting (width, 200 HU; level, 40 HU). Readers recorded the origin, numbers of branches and the presence or absence of the common trunk. The number of singular artery braches was 2 (n=29, 18.6%), 3 (n=123, 78.8%) or 4 (n=4, 2.6%).In cases of two branches, majority of arteries had common trunk at its origin (21 of 29, 72.4%). In cases of three branches, majority of arteries had a common trunk (107 of 123, 87%). In cases of 4 branches, 3 cases demonstrated common trunk from upper lobar artery and additional branches from upper lobar artery and pars interlobar artery. There is significant anatomic variation in the origin, branches and common trunk of the singular artery. Knowledge of this variation can help us to reduce post-op complication.

Si Ahmed D is working under Department of internal medicine, CHU Bejaia as a Faculty of Medicine of Bejaia at University Abderrahmane Mira, Bejaia, Algeria. Currently, he is researching on interstitial lung disease (ILD).

Interstitial lung disease (ILD) is a frequent failure of Systemic Scleroderma (ScS), mainly in diffuse forms of the disease. Even if it is severe in about 16% of patients, it now represents the leading cause of morbidity and mortality in the ScS. Thus, the main objective of our study was to specify the frequency of lung disease interstitial Fibrosing, and correlations with the type of scleroderma. Our study was prospective. From January 2008 to this day, we have included any patient, over the age of 16 years which featured a Systemic Scleroderma meeting the criteria for classification, Leroy and modified Medsger. Our patients had benefited from a systematic search of lung damage. We collected 75 patients. It is 63 women and 12 men. The average age of the patients at the inclusion is 41 + 1.4 [22-72 years]. Lung damage was found in 18 patients. Lung damage was defined on computed tomography coupled with functional data database. It was fifteen diffuse forms and three limited cutaneous Systemic Scleroderma. Immunosuppressive therapy was introduced in ten patients and challenged to counter major indications. The PIF is a frequent violation of ScS. It is a long time asymptomatic and the regular monitoring of patients is essential to the track early and initiate immunosuppressive therapy when the evolution of the disease is rapid. The benefits of currently used therapies are limited. The improvement of knowledge on the pathophysiology and development of new therapeutic strategies is essential to improve the management of patients. The regular monitoring of patients is essential to the track early and initiate immunosuppressive therapy when the evolution of the disease is rapid. The benefits of currently used therapies are limited. The improvement of knowledge on the pathophysiology and development of new therapeutic strategies is essential to improve the management of patients.

Hanna Schmidt is studying medicine since 2010 at Ulm University (Germany). From 2013 to 2016 she did her Doctorate in the Institute of General Physiology. Her thesis is currently under revision. She is working in the field of lung epithelial physiology and her research focuses on water and ion transport and epithelial barrier function.

The airway epithelium forms the first defense line against airborne pathogens. Its tightness depends on tight junction (TJ) complexes. Disturbances of TJ result in epithelial barrier damage facilitate pathogen invasion and thereby aggravate chronic inflammatory lung diseases. The cytokine interleukin-13 (IL-13) has been shown to play a pivotal role in inflammatory lung diseases as asthma or COPD. Whereas increased mucus production is a well described IL-13 effect, its impact on barrier function is hardly elaborated. Therefore, our study aimed on the effect of IL-13 on barrier function and TJ of airway epithelia. IL-13 exposure of primary human tracheal epithelial cells (hTEpC) cultivated as air-liquid-interface reduced transepithelial electrical resistance and increased permeability for sodium fluorescein. RT-PCR experiments revealed reduced mRNA transcript levels of the TJ proteins claudin 8, 9 and 16 and upregulation of the ubiquitin E2 ligase (UBE2Z). Immuncytochemical experiments revealed reduced apicolateral localization and an intracellular accumulation of TJ proteins in IL-13 treated hTEpC. By contrast, the lateral localization of the adherens junction protein E-cadherin remained unaffected by IL-13. Janus kinase inhibitors abolished IL-13 effects. Proximity ligation assays demonstrated ubiquitination of TJ proteins as well as interaction of ZO 1 and several claudins with the ubiquitin conjugating enzyme UBE2Z. Our results demonstrate, that IL-13 impairs airway epithelial barrier by internalization of TJ proteins via an ubiquitin dependent mechanism. Therefore, IL-13 signaling could be a promising therapeutic target to prevent epithelial dysfunction in inflammatory lung diseases.

An Associate Professor, Dr. Islam has been at the University of Nebraska College of Public Health since 2007. He is currently Chair, Department of Epidemiology Graduate Program Studies and PI for the PCORI grant on late stage lung cancer treatment. In 2014, Dr Islam received the UNMC College of Public Health Faculty Research Award He has taught numerous graduate level courses in disease epidemiology and infections disease. He served on the Editorial Board, Journal of Immigrant and Minority Health from 2009-present and on the Editorial Board, Journal of International Cancer Educationfrom 2013 to the present.

Advanced non-small cell lung cancer is a fatal disease disproportionately affecting older patients. Several treatments exist that have similar effectiveness; however, types and frequencies of toxic effects differ and may determine the preferred regimen for an individual patient. Optimal treatment planning involves decision making processes which actively involve patients and physicians together. No guidelines exist for communicating patient preferences of adverse events to physicians. Lack of such knowledge is a major problem because integration of patient preferences into clinical decision-making is expected to improve patient satisfaction, quality of life, and treatment adherence. Our research goal was to integrate lung cancer patient treatment preferences into clinical treatment planning. Our objective was to determine the best approach for translating patient adverse events preferences into real-life drug choices, and assess the impact of communicating these choices to physicians. Our central hypothesis was that toxicity profiles and other treatment-related adverse events are important determinants of patient-centered treatment choices. We collaborated with ten community based cancer treatment centers in four states and engaged dozens of clinicians. We tracked patient preferences through at least two chemotherapy cycles. Our UNMC three-year Patient Centered Outcomes Research Institute study was completed the end of June 2016. We will present patient centered tools developed in collaboration with patients and their caregivers that may be replicated at low cost. We will offer preliminary findings of the study in this poster presentation including